BU 224 hydrochloride

Research use only, not for human use.

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.(In Vivo):BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.

——

Others

Other Targets

——

——

——

205437-64-5

233.7

C12H12ClN3

>98% (HPLC)

——

C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl

——

(-20℃)

With Ice Pack

≥ 2 years